exhibit 10 2 Search Results


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Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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CH Instruments chi-squared test
Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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ATCC activity against b subtilis atcc 67736
Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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ATCC strain 102 na3t exhibited dna dna relatedness values
Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
Strain 102 Na3t Exhibited Dna Dna Relatedness Values, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Aegera Inc aeg35156/ gem®640
Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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Moderna lipid components
Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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Esri inc arcgis 10.2
Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and <t>oncolytic</t> viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented
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Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and oncolytic viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented

Journal: Journal of Translational Medicine

Article Title: Inducing expression of ICOS-L by oncolytic adenovirus to enhance tumor-specific bi-specific antibody efficacy

doi: 10.1186/s12967-024-05049-2

Figure Lengend Snippet: Cytotoxic activity of T cells in combination with EGFRxCD3 BsAb and oncolytic viruses. A Viruses infectivity quantification of A375 tumor cells by RT-qPCR. B Overtime (24 h, 48 h, 4 days) A375 tumor cells viability exposed to 100vp/target cells of vehicle (v), ONCOS-102 or ONCOS-204 virus, assessed by absorbance (490 nm). n = 2 repeats. C A375 tumor cells viability exposed to 100vp/target cells of vehicle, ONCOS-102 or ONCOS-204 virus. Viability assessed 24 h, 48 h and 4 days after PBMCs and BsAb addition. Dot horizontal line corresponds to the medium background absorbance. D specific PBMCs cytotoxic capacity induced by BsAb and vehicle, ONCOS-102 or ONCOS-204 virus. C , D , n = 4. Friedman test with Dunn’s correction was used to compare the groups of paired samples exposed to different conditions. *p < 0.05, **p < 0.01. Medians are represented

Article Snippet: While no significant reduction in viability observed after 24 h, ONCOS-102 exhibited stronger oncolytic capacity compared to the vehicle virus and ONCOS-204 at a similar vp/target cell concentration at 48 h and 4 days after infection (Fig. B).

Techniques: Activity Assay, Infection, Quantitative RT-PCR, Virus